The National Institutes of Health has awarded a group of researchers from Massachusetts General Hospital, Boston Medical Center and Brigham and Women's Hospital a $25 million grant to determine the most effective treatment for the most severe form of peripheral artery disease, which can lead to amputation.
The four-year trial will enroll 2,100 patients at 120 clinical centers in the U.S. and Canada and will compare traditional bypass surgery with the less invasive alternative of endovascular treatment for patients with critical limb ischemia, or CLI.
"This is a huge deal because CLI affects thousands of people in this country alone," said Dr. Alik Farber, chief of the division of vascular and endovascular surgery at BMC and one of the trial's principal investigators. "The problem is it's unclear which procedure is better in terms of saving legs."
Endovascular treatment is a smaller procedure with less risk, Farber said, but it also is thought to be not as durable, meaning that the patient may have to have it done more than once.
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